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Related Experiment Videos

Elastin and collagen remodeling in emphysema. A scanning electron microscopy study

G A Finlay1, M D O'Donnell, C M O'Connor

  • 1Department of Medicine and Therapeutics, University College Dublin, Ireland.

The American Journal of Pathology
|October 1, 1996
PubMed
Summary

Emphysema involves elastin damage and altered collagen structure. This study reveals disrupted elastin and thickened, disorganized collagen in emphysematous lungs, suggesting abnormal collagen remodeling contributes to the disease.

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Area of Science:

  • Pulmonary Medicine
  • Pathology
  • Biomaterials Science

Background:

  • Emphysema is characterized by elastin degradation.
  • Pulmonary remodeling is a complex process in emphysematous lungs.
  • Extracellular matrix changes are implicated in emphysema pathogenesis.

Purpose of the Study:

  • To investigate extracellular matrix remodeling in emphysema.
  • To ultrastructurally examine elastin and collagen in emphysematous lungs.
  • To compare emphysema models and human samples.

Main Methods:

  • Induced emphysema in rats via porcine pancreatic elastase.
  • Examined human lung samples from carcinoma resections.
  • Utilized scanning electron microscopy with stereo-pair imaging after alkali and acid treatments to visualize collagen and elastin templates.

Related Experiment Videos

  • Quantified emphysema severity using mean linear intercept.

    • Main Results:

    • Emphysematous lungs showed disrupted, fenestrated elastin sheets.
    • Elastase-induced emphysema featured increased collagen fibril thickness compared to controls.
    • Human emphysematous lungs exhibited thickened, disorganized collagen deposition.

    Conclusions:

    • Findings support a novel concept of increased collagen deposition in emphysema.
    • Aberrant collagen remodeling is implicated in the pathogenesis of emphysema.
    • Ultrastructural analysis reveals significant extracellular matrix alterations in emphysema.