Blood density monitoring during dialysis

Continuous monitoring of blood density (BD) was preformed in 4 stable dialysis patients in 20 sessions using a density meter based on a mechanical oscillator technique. Mean predialysis and postdialysis BDs were 1.0427 +/- 0.0031 g/cm3 and 1.0502 +/- 0.0055 g/cm3, respectively. For similar predialysis to postdialysis total body water reduction, significant difference in the mean BD increase was found between hypotensive and nonhypotensive groups (1.29 +/- 0.07%, 0.47 +/- 0.12%, respectively; p < 0.001). Eight hypotensive episodes occurred during 6 sessions. The mean value of the blood density changes slope (dBD/dr) during the 5 min preceding a hypotensive episode increased about 2.5 times more than did the mean of the predialysis to postdialysis blood density slope (27.6 +/- 2.2 g/cm3.min.10(-5), 10.5 +/- 0.4 g/cm3.min.10(-5), respectively; p < 0.001) under the condition of a constant ultrafiltration rate of 18.9 +/- 0.6 ml/min. Continuous monitoring of blood density allows abrupt change in plasma volume to be identified and seems to have a potential utility to the prevention of symptomatic hypotension episodes in patients receiving hemodialysis.