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Related Experiment Video

Updated: Jul 16, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

Chemokine receptors: structure, function and role in microbial pathogenesis

¹Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Cytokine & Growth Factor Reviews

|June 1, 1996

Summary

Chemokine receptors are key targets for anti-inflammatory drugs. These receptors also facilitate infections like HIV and malaria, highlighting their dual role in disease.

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Identification of Functional Protein Regions Through Chimeric Protein Construction

Identification of Functional Protein Regions Through Chimeric Protein Construction

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Last Updated: Jul 16, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

Published on: March 10, 2018

Identification of Functional Protein Regions Through Chimeric Protein Construction

Identification of Functional Protein Regions Through Chimeric Protein Construction

Published on: January 8, 2019

Area of Science:

Immunology
Cell Biology
Virology

Background:

The chemokine superfamily comprises over 20 leukocyte chemoattractants binding to G protein-coupled receptors.
Leukocyte subtypes exhibit specific chemokine preferences based on receptor distribution.
Chemokine receptors signal via a common Gi-type G protein.

Purpose of the Study:

To explore the therapeutic potential of chemokine receptors as targets for anti-inflammatory drugs.
To understand the pathological roles of specific chemokine receptors in infectious diseases.

Main Methods:

Analysis of chemokine superfamily structure and function.
Investigation of G protein-coupled receptor signaling pathways.
Examination of chemokine receptor involvement in viral and parasitic infections.

Main Results:

Chemokine receptors are implicated in inflammatory pathologies.
CC CKRS acts as an entry factor for human immunodeficiency virus 1 (HIV-1).
ONCC functions as an entry factor for Plasmodium vivax, a cause of malaria.

Conclusions:

Chemokine receptors represent promising targets for developing leukocyte-selective anti-inflammatory therapies.
Targeting specific chemokine receptors could offer novel strategies for combating HIV and malaria.