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GABAergic agents modify imipramine analgesia

P M Ballal1, S N Mandhane, C T Chopde

  • 1Department of Pharmaceutical Sciences, Nagpur University Campus, Nagpur.

Indian Journal of Physiology and Pharmacology
|January 1, 1996
PubMed
Summary

Imipramine

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Imipramine (IMA) is an antidepressant with known analgesic properties.
  • The role of the GABAergic system in imipramine's pain-relieving effects is not fully understood.

Purpose of the Study:

  • To investigate the influence of GABA agonists and antagonists on the analgesic activity of imipramine.
  • To elucidate the involvement of GABA receptors in imipramine-induced analgesia.

Main Methods:

  • Utilized the hotplate method in animal models to assess pain response.
  • Administered various GABAergic agents (agonists, antagonists, synthesis/degradation inhibitors) in conjunction with imipramine.

Main Results:

  • GABA receptor agonists (muscimol, baclofen) and a GABA-T inhibitor (aminooxyacetic acid) enhanced imipramine's analgesic effect.
  • GABA receptor antagonists (bicuculline, delta-amino-n-valeric acid) and a GABA synthesis inhibitor (thiosemicarbazide) attenuated imipramine analgesia.

Conclusions:

  • Imipramine's analgesic action appears to be mediated by the central GABAergic system.
  • Modulation of GABAergic neurotransmission and/or GABA receptors plays a significant role in imipramine's pain-relief mechanisms.

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