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Studies on epoxy compound fixation

H W Sung1, W H Cheng, I S Chiu

  • 1Department of Chemical Engineering, National Central University, Chung-Li, Taiwan, Republic of China.

Journal of Biomedical Materials Research
|January 1, 1996
PubMed
Summary
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New epoxy compounds offer a pliable alternative to glutaraldehyde for fixing bioprostheses. Epoxy-fixed tissues demonstrate improved flexibility compared to glutaraldehyde-fixed tissues, with potential for optimizing bioprosthetic development.

Area of Science:

  • Biomaterials science
  • Tissue engineering
  • Biomedical engineering

Background:

  • Bioprostheses require fixation and sterilization before implantation.
  • Glutaraldehyde is a common fixative but causes tissue stiffening and calcification.
  • Alternative fixatives are needed to improve bioprosthetic properties.

Purpose of the Study:

  • To investigate fixation rates and crosslinking densities of biological tissues fixed with epoxy compounds.
  • To compare epoxy compounds with glutaraldehyde as fixatives for bioprostheses.
  • To evaluate the impact of epoxy compound structure and fixation conditions on tissue properties.

Main Methods:

  • Fixation of biological tissues using various epoxy compounds and glutaraldehyde (control).
  • Determination of fixation rates via fixation indices.

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  • Measurement of crosslinking densities using denaturation temperatures.

    • Main Results:

    • Epoxy-fixed tissues were more pliable than glutaraldehyde-fixed tissues.
    • Monofunctional epoxy compounds yielded more pliable tissues than multifunctional ones.
    • Glutaraldehyde fixation was faster and resulted in higher crosslinking density than epoxy fixation.

    Conclusions:

    • Epoxy compounds present a promising alternative fixative for bioprostheses, offering improved pliability.
    • Fixation conditions (pH, temperature) influence epoxy compound fixation rates.
    • Further optimization of epoxy fixation may lead to enhanced bioprosthetic materials.