Correlation between effective peritoneal blood flow, blood pressure, and peritoneal transfer rates

The aim of the studies was an evaluation of the correlation between effective peritoneal blood flow (EPBF), blood pressure, and peritoneal transfer during intermittent peritoneal dialysis (IPD). In 20 IPD patients it was shown that EPBF does not depend on either systolic or diastolic blood pressure. Differences in EPBF did not influence peritoneal transfer of small solutes and total protein during the first 25 minutes of dwell, but EPBF dependence of transfer was shown in the later periods of the dwell. Peritoneal transfer rates were greater with higher systolic blood pressure; the significant changes were shown at the beginning (for bicarbonate and total carbon dioxide), in the middle (for urea), and at the end (for uric acid) of the dwell time. Differences in diastolic pressure influenced peritoneal transfer predominantly during the first 25 minutes of dwell, although significant changes during the entire dwell were also observed. Our results indicate that the influence of both EPBF and blood pressure on transport kinetics depends on dwell time: in the first minutes of dwell diastolic blood pressure can predominantly contribute to transfer rates, in later periods the greater role of EPBF in the determination of transfer rates cannot be excluded.