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Biodegradable injectable implant systems for long term drug delivery using poly (lactic-co-glycolic) acid copolymers
1College of Pharmaceutical Sciences, Kasturba Medical College, Manipal, India.
The Journal of Pharmacy and Pharmacology
|July 1, 1996
Summary
Poly (lactide-co-glycolide) (PLG) microspheres and in situ gels effectively deliver diclofenac sodium for sustained pain relief in arthritic rats. Microspheres provided longer drug release, while gels offered higher initial drug concentration and inflammation inhibition.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Pharmacology
Background:
- Poly (lactide-co-glycolide) (PLG) is a key biodegradable polymer for controlled drug delivery.
- Diclofenac sodium is a non-steroidal anti-inflammatory drug used for chronic pain management.
Purpose of the Study:
- To evaluate PLG (50:50) copolymer for subcutaneous delivery of diclofenac sodium.
- To compare the efficacy of PLG microspheres versus in situ gel-forming systems for sustained drug release and anti-inflammatory effects.
Main Methods:
- Preparation of diclofenac sodium-loaded PLG (50:50) microspheres and in situ gel-forming systems.
- Subcutaneous injection in adjuvant-induced arthritic rats.
- Pharmacokinetic and pharmacodynamic studies to assess drug plasma levels and anti-inflammatory activity.
Main Results:
- PLG microspheres maintained therapeutic drug levels for approximately 16 days.
- In situ gel-forming systems achieved higher peak plasma concentrations and enhanced inflammation inhibition for about 10 days.
- Both systems demonstrated potential for long-term drug delivery.
Conclusions:
- Injectable PLG (50:50) microspheres and in situ gel systems are promising for sustained subcutaneous delivery of diclofenac sodium.
- These systems offer viable options for long-term management of chronic inflammatory conditions.
- The choice between microspheres and in situ gels depends on desired release profile and therapeutic outcome.