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Published on: January 29, 2012
Phorbol ester intracerebroventricularly induces a behavioral hypoactivity that is not affected by chronic or acute
Y Patishi1, Y Bersudsky, R H Belmaker
1Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel.
Abstract:
Chronic lithium treatment in rats has been reported to decrease protein kinase C alpha isozyme in hippocampal membranes. We gave phorbol ester, a protein kinase C activator, i.c.v. to rats treated with acute or chronic lithium. Low dose phorbol ester causes a marked hypoactivity and high dose phorbol ester causes a barrel rolling behavior, but no behavioral interactions with lithium treatment were observed.
