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Related Experiment Videos

Intraseptal microinjection of beta-funaltrexamine blocked a microwave-induced decrease of hippocampal cholinergic

H Lai1, M A Carino, A Horita

  • 1Department of Pharmacology, University of Washington, Seattle 98195, USA. hlai@u.washington.edu

Pharmacology, Biochemistry, and Behavior
|March 1, 1996
PubMed
Summary

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Microwave exposure decreased brain cholinergic activity via mu-opioid receptors in rats. This suggests that microwaves may activate the brain's natural opioid system.

Area of Science:

  • Neuroscience
  • Electromagnetic field effects
  • Neuropharmacology

Background:

  • Cholinergic activity in the hippocampus is crucial for memory and cognitive functions.
  • Endogenous opioids play a role in modulating neuronal activity and pain perception.
  • The effects of microwave exposure on brain neurochemistry are not fully understood.

Purpose of the Study:

  • To investigate the impact of pulsed 2450-MHz microwave exposure on cholinergic activity in the rat hippocampus.
  • To determine the role of mu-opioid receptors in mediating microwave-induced neurochemical changes.
  • To explore the hypothesis that microwaves activate endogenous opioid systems in the brain.

Main Methods:

  • Acute exposure of rats to pulsed microwaves (2 microseconds pulse width, 500 pulses/s) at 1 mW/cm2 (SAR 0.6 W/kg) for 45 minutes.

Related Experiment Videos

  • Measurement of sodium-dependent high-affinity choline uptake in the hippocampus to assess cholinergic activity.
  • Intraseptal microinjection of beta-funaltrexamine (a mu-opioid receptor antagonist) prior to microwave exposure.

    • Main Results:

    • Microwave exposure significantly decreased cholinergic activity in the hippocampus.
    • Pre-treatment with beta-funaltrexamine blocked the microwave-induced decrease in cholinergic activity.
    • The findings indicate that mu-opioid receptors in the septum are involved in this effect.

    Conclusions:

    • Microwave exposure at a whole-body specific absorption rate of 0.6 W/kg can decrease hippocampal cholinergic activity.
    • Mu-opioid receptors located in the septum mediate this microwave-induced neurochemical alteration.
    • These results support the hypothesis that microwaves can activate endogenous opioid pathways in the brain.