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An adolescent hepatitis B immunisation program. The Preston experience

R Howsam, A Dunn

    Australian Family Physician
    |March 1, 1996
    PubMed
    Summary
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    A 1993 adolescent hepatitis B vaccination program in Preston, Melbourne, achieved high completion rates (78%) with no reported side effects. The program demonstrated excellent student acceptance and cost-effectiveness for hepatitis B immunization.

    Area of Science:

    • Public Health
    • Immunology
    • Vaccinology

    Background:

    • Hepatitis B poses a significant global health risk, particularly among adolescents.
    • Effective vaccination programs are crucial for preventing hepatitis B transmission and long-term sequelae.
    • School-based immunization initiatives offer a practical approach to achieving high coverage rates.

    Purpose of the Study:

    • To evaluate the feasibility, acceptance, and outcomes of an adolescent hepatitis B immunization program in a school setting.
    • To assess the completion rates and safety profile of a three-dose hepatitis B vaccine schedule in Year 9 students.
    • To determine the cost-effectiveness of a community-funded school-based hepatitis B vaccination program.

    Main Methods:

    • A prospective cohort study involving Year 9 students in eight post-primary schools in Preston, Melbourne.

    Related Experiment Videos

  • Administration of a three-dose Engerix B Adult Vaccine course funded by the City of Preston.
  • Monitoring of student enrollment, program completion, and adverse events following immunization.

    • Main Results:

    • 857 Year 9 students were offered the vaccine; 85% elected to participate.
    • A high program completion rate of 78% was achieved, with 95% of participants completing the three-dose schedule.
    • No adverse side effects were reported across 2041 administered vaccine doses, indicating excellent tolerability.

    Conclusions:

    • The adolescent hepatitis B immunization program in Preston was highly successful, demonstrating excellent student acceptance and adherence.
    • The school-based vaccination strategy proved to be a safe, effective, and well-tolerated method for hepatitis B prevention in adolescents.
    • The program achieved significant public health impact at a cost of $34 per completed vaccination course.