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Related Experiment Videos

Plasma ionized magnesium during acute hyperventilation in humans

G Hafen1, R Laux-End, A C Truttmann

  • 1Department of Pediatrics, University of Berne, Switzerland.

Clinical Science (London, England : 1979)
|September 1, 1996
PubMed
Summary

Respiratory alkalosis from overbreathing reduces ionized magnesium levels. This may explain tetany and cardiac issues linked to hyperventilation, highlighting magnesium

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Area of Science:

  • Cardiology
  • Physiology
  • Biochemistry

Background:

  • Respiratory alkalosis is linked to tetany, cardiac arrhythmias, and coronary vasoconstriction.
  • Magnesium is crucial for membrane function; depletion is associated with cardiac issues.
  • New magnesium-selective electrodes allow measurement of circulating ionized magnesium.

Purpose of the Study:

  • To investigate the effect of induced respiratory alkalosis on circulating ionized magnesium levels.
  • To determine if hyperventilation alters total plasma magnesium or ionized magnesium fractions.

Main Methods:

  • Eight healthy subjects voluntarily overbreathed for 30 minutes to induce respiratory alkalosis.
  • Total plasma magnesium, ionized magnesium, and free magnesium fractions were measured.

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  • Relative intravascular magnesium mass was calculated using plasma magnesium and hematocrit.

    • Main Results:

    • Hyperventilation did not alter total plasma magnesium concentration.
    • Ionized magnesium concentration significantly decreased by 0.05 mmol/l (median).
    • The free magnesium fraction and relative intravascular magnesium mass also significantly decreased.

    Conclusions:

    • Acute overbreathing reduces circulating ionized magnesium concentration and intravascular magnesium mass.
    • Extracellular magnesium deficiency may contribute to tetany and cardiac complications during hyperventilation.