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Early asymmetric IUGR and aneuploidy
C Anandakumar1, S Chew, Y C Wong
1Department of Obstetrics and Gynecology, National University of Singapore, Singapore.
The Journal of Obstetrics and Gynaecology Research
|August 1, 1996
Summary
Fetal karyotyping may be unnecessary for structurally normal fetuses with early-onset asymmetric growth retardation diagnosed between 23-29 weeks gestation. This finding aids in optimizing prenatal diagnostic strategies for intrauterine growth restriction.
Area of Science:
- Prenatal diagnostics
- Fetal medicine
- Genetics
Background:
- Asymmetric growth retardation (IGR) is a common condition in pregnancy.
- Chromosomal abnormalities can contribute to fetal growth restriction.
- Early identification of fetal aneuploidy is crucial for management.
Purpose of the Study:
- To investigate the incidence of chromosomal abnormalities in fetuses with asymmetric growth retardation.
- To assess the correlation between structural defects, gestational age at diagnosis, and aneuploidy in IGR fetuses.
Main Methods:
- A cohort of 71 singleton pregnancies with asymmetric growth retardation (15-35 weeks gestation) was studied.
- Detailed ultrasonography was performed to identify structural malformations.
- Fetal karyotyping was conducted for all participants.
Main Results:
- Overall, 9.9% of fetuses with asymmetric growth retardation had abnormal karyotypes.
- In cases with structural defects, the chromosomal abnormality rate was 21%.
- Structurally normal fetuses diagnosed before 23 weeks showed a 20% aneuploidy rate, while none were found between 23-29 weeks.
Conclusions:
- Fetal karyotyping may not be essential for structurally normal fetuses with early-onset asymmetric growth retardation (23-29 weeks gestation).
- Further prospective studies are needed to confirm these findings.
- This suggests a potential refinement in the diagnostic approach for intrauterine growth restriction.