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Related Experiment Videos

Isoniazid-induced fever

C H Lee1, T R Hsiue, C W Chen

  • 1Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, ROC.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|August 1, 1996
PubMed
Summary
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Isoniazid (INH), a common tuberculosis treatment, can rarely cause isolated fever without other symptoms. This drug-induced fever may mimic infection, so consider INH when fever arises during TB therapy.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Tuberculosis (TB) treatment commonly involves multiple drugs, including isoniazid (INH).
  • Adverse drug reactions can complicate TB therapy and require careful diagnosis.
  • Distinguishing drug-induced fever from infectious fever is crucial for patient management.

Observation:

  • A patient with miliary TB developed a high fever on day seven of treatment with INH, ethambutol, rifampicin, and pyrazinamide.
  • Initial investigations revealed no signs of hypersensitivity, infection, or other abnormalities.
  • Fever resolved upon INH discontinuation and recurred upon rechallenge, confirming INH as the cause.

Findings:

  • Isoniazid (INH) can induce isolated fever as a rare adverse effect.

Related Experiment Videos

  • This drug-induced fever may present without other typical signs of hypersensitivity or infection.
  • Diagnostic workup for fever during anti-TB treatment should consider INH-induced fever.

    • Implications:

    • Clinicians should consider isoniazid-induced fever in patients with unexplained fever during TB treatment.
    • Early recognition and management of INH-induced fever can prevent misdiagnosis and ensure treatment continuity.
    • This case highlights the importance of vigilant monitoring for rare adverse drug reactions in infectious disease management.