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[Infectious toxic hypotension--effect and dosage of midodrine (author's transl)]
Abstract:
A new alpha-sympathicomimetic drug with peroral effect is midodrine. The effective oral dosage in infancy and childhood is 0.06 mg/kg/dosi. The therapeutic effect, comparing the drug with etilefrin is shown in 120 children with pneumonia, enteritis, meningitis in a random study. The results give an increase in blood pressure and a decrease in heart frequency, statistically proved, on the first day of treatment. Therefore it seems that midodrine is qualified for the treatment of hypotension in infectious diseases.
Insights
Midodrine, a new oral alpha-sympathicomimetic drug, effectively treats hypotension in children with infectious diseases. Studies show it increases blood pressure and decreases heart rate, proving beneficial in pediatric care.
Area of Science:
- Pharmacology
- Pediatrics
- Internal Medicine
Background:
- Hypotension is a common complication in pediatric infectious diseases.
- Alpha-sympathicomimetic drugs are used to manage low blood pressure.
- Midodrine is a novel oral sympathicomimetic agent.
Purpose of the Study:
- To evaluate the efficacy of midodrine in treating hypotension in children.
- To compare the therapeutic effects of midodrine with etilefrine.
- To assess the safety and effectiveness of midodrine in pediatric patients with infectious conditions.
Main Methods:
- A randomized study involving 120 children diagnosed with pneumonia, enteritis, or meningitis.
- Administration of midodrine at an effective oral dosage of 0.06 mg/kg/dosi.
- Comparison of hemodynamic parameters (blood pressure, heart rate) between midodrine and etilefrine treatment groups.
Main Results:
- Midodrine demonstrated a statistically significant increase in blood pressure on the first day of treatment.
- A significant decrease in heart rate was observed in children treated with midodrine.
- The drug showed comparable or superior therapeutic effects to etilefrine.
Conclusions:
- Midodrine is a qualified therapeutic option for managing hypotension in pediatric infectious diseases.
- The drug offers a safe and effective treatment for low blood pressure in infants and children.
- Early administration of midodrine leads to rapid and significant improvements in hemodynamic stability.