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Perfluorochemical oxygen carriers: potential uses in neurosciences
D E Sakas1, G Stranjalis, K Whittaker
1Neuroscience Unit, Walsgrave Hospital, Coventry, England.
Cerebrovascular and Brain Metabolism Reviews
|January 1, 1996
Summary
Perfluorochemicals (PFCs) show promise as oxygen carriers, especially second-generation PFCs for neurosciences. Advances in PFC technology are overcoming limitations, enabling new clinical and research applications.
Area of Science:
- Biomedical Engineering
- Neuroscience
- Materials Science
Background:
- Perfluorochemicals (PFCs) are synthetic compounds with high oxygen and carbon dioxide solubility and biological inertness.
- First- and second-generation PFCs have been developed as potential oxygen carriers.
- Logistical challenges related to in vivo molecular behavior have limited widespread PFC use.
Purpose of the Study:
- To review recent developments in first- and second-generation PFC oxygen carriers.
- To emphasize the implications of the latest research in clinical and experimental neurosciences.
- To explore current and potential applications of PFCs in medicine and research.
Main Methods:
- Review of recent scientific literature on perfluorochemicals.
- Analysis of PFC properties relevant to oxygen transport and biological inertness.
- Discussion of technological advancements in PFC development.
Main Results:
- Advances in PFC technology have renewed interest in their clinical and experimental applications.
- Second-generation PFCs show potential for cerebral protection.
- PFCs are being investigated for diverse applications including neurosurgery, organ transplantation, and cancer therapy.
Conclusions:
- PFCs offer significant potential as oxygen carriers, particularly in neurosciences.
- Ongoing research and technological advancements are expanding the clinical utility of PFCs.
- PFCs are poised for broader applications in diagnostics and therapeutics.