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Related Experiment Videos

Gamma knife radiosurgery in children

G S Baumann1, W M Wara, D A Larson

  • 1London Regional Cancer Clinic, Ont., Canada.

Pediatric Neurosurgery
|January 1, 1996
PubMed
Summary

Pediatric radiosurgery effectively treated arteriovenous malformations and various neoplasms. While complete arteriovenous malformation obliteration occurred in some, side effects like T2 changes and necrosis were observed in a subset of patients.

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Area of Science:

  • Pediatric Neurosurgery
  • Radiation Oncology
  • Neurology

Background:

  • Radiosurgery is an established treatment for pediatric central nervous system (CNS) lesions.
  • Data on long-term outcomes and specific side effects in pediatric populations undergoing radiosurgery for arteriovenous malformations (AVMs) and neoplasms are crucial.

Purpose of the Study:

  • To evaluate the efficacy and safety of radiosurgery in pediatric patients with AVMs and CNS neoplasms.
  • To assess outcomes such as complete obliteration rates for AVMs and local control rates for neoplasms.
  • To identify and report adverse events associated with pediatric radiosurgery.

Main Methods:

  • Retrospective analysis of 52 pediatric patients treated with radiosurgery at a single institution.
  • Review of treatment outcomes for arteriovenous malformations (n=27) and neoplasms (n=25).

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  • Assessment of imaging and clinical data for complete obliteration, local control, rebleeding, and adverse events like T2 changes and necrosis.

    • Main Results:

    • Complete obliteration was achieved in 4 of 12 patients with AVMs imaged >2 years post-treatment; one patient experienced rebleeding.
    • Symptomatic T2 changes were observed in 2 patients with AVMs.
    • Local control rates for neoplasms included: 5/7 low-grade gliomas, 5/14 high-grade gliomas, 4/5 craniopharyngiomas, and 3/3 sarcomas.
    • Three patients treated for neoplasms developed post-radiosurgery necrosis.

    Conclusions:

    • Pediatric radiosurgery demonstrates potential for achieving complete obliteration in AVMs and local control in various CNS neoplasms.
    • Close monitoring for adverse events, including T2 changes and radiation necrosis, is essential in pediatric patients undergoing radiosurgery.
    • Further research is warranted to optimize treatment strategies and minimize long-term sequelae in pediatric neuro-oncology and vascular malformation management.