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Genetic variant near cytosolic phospholipase A2 associated with schizophrenia
C J Hudson1, J L Kennedy, A Gotowiec
1Schizophrenia Program, Clarke Institute of Psychiatry, Toronto, Ontario, Canada.
Abstract:
Two studies were undertaken to determine a possible genetic basis for alterations in phospholipid metabolism in schizophrenia. Initial results demonstrated an association in 65 schizophrenics compared with a matched normal control population. A follow-up haplotype relative risk study of 44 triads (mother, father, affected offspring), confirmed the results seen in the association study. Results suggest that a genetic variant near the promotor region of the gene for cytosolic phospholipase A2, the rate-limiting enzyme in the synthesis of prostaglandins from arachindonic acid, is associated with schizophrenia.
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