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Updated: Jul 27, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
HLA-dependent TNF secretory response may provide an immunogenetic link between pre-eclampsia and type 1 diabetes
Abstract:
Tumour necrosis factor (TNF) may be relevant to the pathogenesis of both pre-eclampsia and type 1 diabetes, and there is evidence than human TNF alpha responses to stimuli are HLA-DR dependent. To test the hypothesis that pre-eclampsia and diabetes may share a common immunogenetic susceptibility, 92 pre-eclampsia patients were compared with 264 general population controls. The relative frequencies of individual HLA-DR antigens in pre-eclamptics were found to correlate with reported relative TNF alpha responses for those antigens. Moreover, putative high responder HLA-DR1, DR3 and DR4 alleles were significantly (p < 0.001) more frequent in pre-eclampsia patients (79%) than in controls (59%). This hypothesis could explain the weak association between pre-eclampsia and diabetes and may help resolve the apparently conflicting literature on HLA in pre-eclampsia.
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