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Biomarker expression in prostatic intraepithelial neoplasia
1Department of Pathology, University of Alabama at Birmingham 35291-0007, USA.
European Urology
|January 1, 1996
Summary
Prostatic intraepithelial neoplasia (PIN) shares cellular similarities with prostate cancer (PCa), indicating it is a preinvasive lesion. Biomarker analysis reveals altered cell proliferation, differentiation, and glycosylation in PIN and PCa.
Area of Science:
- Urology
- Oncology
- Cell Biology
Background:
- Prostate cancer (PCa) development involves complex cellular events.
- Prostatic intraepithelial neoplasia (PIN) is a precursor lesion to PCa.
Purpose of the Study:
- To understand cellular events in PIN development.
- To clarify the relationship between PIN and invasive PCa.
Main Methods:
- Review of previous studies on biomarker expression in PIN and PCa.
- Analysis of cellular events and biomarker profiles.
Main Results:
- PIN exhibits altered expression of growth factor receptors (e.g., P185erbB-2, p180erbB-3, c-met), nm-23H1, and PCNA, indicating increased proliferation.
- Decreased expression of prostate-specific antigen (PSA), prostatic acid phosphatase (PAP), and Leu 7 in PIN suggests impaired differentiation.
- Aberrant glycosylation and expression of tumor antigens (TAG-72, Lewis Y) are observed.
- Enhanced expression of proteolytic enzymes (cathepsin D, collagenase IV) in PIN may facilitate invasion.
Conclusions:
- PIN shows phenotypic similarities to invasive PCa.
- PIN is a preinvasive lesion of prostate adenocarcinoma.