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Updated: Jul 28, 2026
Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
Published on: November 22, 2019
Neuroendocrine differentiation in the precursors of prostate cancer
1University of Rochester Medical Center, NY 14642, USA.
Objectives:
To review neuroendocrine differentiation in the precursors of prostatic carcinoma (prostatic intraepithelial neoplasia).
Methods:
Background information is given on the prostatic neuroendocrine cell and neuroendocrine differentiation in prostatic carcinoma. Neuroendocrine differentiation in prostatic intraepithelial neoplasia is reviewed.
Results:
Neuroendocrine differentiation occurs in prostatic intraepithelial neoplasia and is intermediate in degree between normal (which has the most cells with neuroendocrine differentiation) and carcinoma.
Conclusion:
Neuroendocrine differentiation in the precursors of prostatic carcinoma may play a role in the pathogenesis of cancer but is speculative at this time. Methods to better assess neuroendocrine differentiation are needed.
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