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Propylthiouracil-induced hepatic damage
S Ozenírler1, C Tuncer, U Boztepe
1Department of Medicine, University of Gazi, Ankara, Turkey.
The Annals of Pharmacotherapy
|September 1, 1996
Summary
Propylthiouracil (PTU) can cause rare but severe liver damage in hyperthyroidism patients. Careful patient screening is crucial to prevent this serious complication.
Area of Science:
- Hepatology
- Endocrinology
- Pharmacology
Background:
- Propylthiouracil (PTU) is a common treatment for hyperthyroidism.
- Hepatotoxicity is a rare but serious adverse effect of PTU.
- The mechanism of PTU-induced liver injury is not fully understood, but immunologic factors are suspected.