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Study of morphology of reactive dissolution interface using fractal geometry
A Tromelin1, J C Gnanou, C Andrès
1Faculté de Pharmacie, Groupe Physico-Chimie et Technologie des Poudres Pharmaceutiques, Université de Bourgogne, Dijon, France.
Journal of Pharmaceutical Sciences
|September 1, 1996
Summary
This study determined the reactive fractal dimension during orthoboric acid dissolution using two Noyes-Whitney equation forms. Findings suggest dissolution initiates at specific sites, potentially creating microporous volumes or cracks.
Area of Science:
- Physical Chemistry
- Materials Science
- Chemical Engineering
Background:
- The Noyes-Whitney equation describes dissolution kinetics.
- Fractal geometry offers insights into complex surface phenomena.
- Understanding dissolution mechanisms is crucial for material processing.
Purpose of the Study:
- To determine the reactive fractal dimension of orthoboric acid powder during dissolution.
- To compare dissolution kinetics using two forms of the Noyes-Whitney equation.
- To hypothesize about the initial stages and mechanisms of dissolution.
Main Methods:
- Utilized two forms of the Noyes-Whitney equation: -dQ/dt = K(Q/Q0)DR/3 and -dQ/dt = K'RDR-3.
- Employed the Richardson plot for data analysis.
- Analyzed previously obtained dissolution data for orthoboric acid powder.
Main Results:
- Calculated the reactive fractal dimension using both equation forms.
- Correlated the results obtained from the two calculation methods.
- Identified a specific population of reactive sites initiating the dissolution process.
Conclusions:
- The dissolution of orthoboric acid likely begins at a distinct set of reactive sites.
- The dissolution process may lead to the formation of microporous volumes or cracks.
- Consistent results from both Noyes-Whitney equation forms support the proposed dissolution hypothesis.