The chemical synthesis of proteins

Concept and early development of solid-phase peptide synthesis.

Methods in enzymology·1997

Increasing mean skin temperature linearly reduces the core-temperature thresholds for vasoconstriction and shivering in humans.

Anesthesiology·1995

Propofol linearly reduces the vasoconstriction and shivering thresholds.

Anesthesiology·1995

Optimal duration and temperature of prewarming.

Anesthesiology·1995

Structure-immunogenicity relationship of melittin, its transposed analogues, and D-melittin.

Journal of immunology (Baltimore, Md. : 1950)·1994

The pupillary light reflex. Effects of anesthetics and hyperthermia.

Anesthesiology·1993

Structural and functional insights into Pseudomonas aeruginosa ApaH, a diadenosine tetraphosphatase crucial for bacterial virulence.

Protein science : a publication of the Protein Society·2026

Catalytic architecture and cyclase-mediated dimerization of a newly identified class III-c lanthipeptide synthetase.

Protein science : a publication of the Protein Society·2026

AVIDbase: A biologically accurate structural dataset of nanobody-antigen complexes.

Protein science : a publication of the Protein Society·2026

Molecular logics in dual sensor regulation of diguanylate cyclase activity-Phosphorylation OR blue-light activation.

Protein science : a publication of the Protein Society·2026

Structural and biophysical characterization of Mycobacterium tuberculosis DciA reveals functional convergence in DnaB helicase recognition.

Protein science : a publication of the Protein Society·2026

Viral PDZ target sequences are not inherently more promiscuous than those derived from endogenous target proteins.

Protein science : a publication of the Protein Society·2026

Evaluation of two approaches for the synthesis of functional sphingosines with mirror symmetric order of reduction and metathesis steps.

Organic & biomolecular chemistry·2026

Organocatalytic Asymmetric Formal Aza-[3 + 2] Cycloaddition via Domino Michael/Acetalization: Stereoselective Access to 3,4-cis-Disubstituted Pyrrolidines and Pot-Economical Total Syntheses of (-)-Kainic Acid and (-)-Domoic Acid.

JACS Au·2026

Introducing Chlorido Cerium Complexes with the Methoxy Kläui Ligand [Co(η5-C5H5){P(O)(OMe)2}3].

Molecules (Basel, Switzerland)·2026

Light-Promoted C-H/C-H Coupling of Imidazo[1,2-a]pyridines with 5-(Hetero)aryl-1,2,5-oxadiazolo[3,4-b]pyrazines over TiO2 and Experimental/In Silico Evaluation of COX-1 and COX-2 Inhibitory Activity.

Molecules (Basel, Switzerland)·2026

Alumina-Templated ortho-Prenylation of Phenols.

Nature communications·2026

Synthesis of 2-thiobenzothiazoles via cascade construction of exocyclic and endocyclic S-C bonds.

Organic & biomolecular chemistry·2026

Related Experiment Videos

The chemical synthesis of proteins

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Concept and early development of solid-phase peptide synthesis.

Increasing mean skin temperature linearly reduces the core-temperature thresholds for vasoconstriction and shivering in humans.

Propofol linearly reduces the vasoconstriction and shivering thresholds.

Optimal duration and temperature of prewarming.

Structure-immunogenicity relationship of melittin, its transposed analogues, and D-melittin.

The pupillary light reflex. Effects of anesthetics and hyperthermia.

Structural and functional insights into Pseudomonas aeruginosa ApaH, a diadenosine tetraphosphatase crucial for bacterial virulence.

Catalytic architecture and cyclase-mediated dimerization of a newly identified class III-c lanthipeptide synthetase.

AVIDbase: A biologically accurate structural dataset of nanobody-antigen complexes.

Molecular logics in dual sensor regulation of diguanylate cyclase activity-Phosphorylation OR blue-light activation.

Structural and biophysical characterization of Mycobacterium tuberculosis DciA reveals functional convergence in DnaB helicase recognition.

Viral PDZ target sequences are not inherently more promiscuous than those derived from endogenous target proteins.

Evaluation of two approaches for the synthesis of functional sphingosines with mirror symmetric order of reduction and metathesis steps.

Organocatalytic Asymmetric Formal Aza-[3 + 2] Cycloaddition via Domino Michael/Acetalization: Stereoselective Access to 3,4-cis-Disubstituted Pyrrolidines and Pot-Economical Total Syntheses of (-)-Kainic Acid and (-)-Domoic Acid.

Introducing Chlorido Cerium Complexes with the Methoxy Kläui Ligand [Co(η5-C5H5){P(O)(OMe)2}3].

Light-Promoted C-H/C-H Coupling of Imidazo[1,2-a]pyridines with 5-(Hetero)aryl-1,2,5-oxadiazolo[3,4-b]pyrazines over TiO2 and Experimental/In Silico Evaluation of COX-1 and COX-2 Inhibitory Activity.

Alumina-Templated ortho-Prenylation of Phenols.

Synthesis of 2-thiobenzothiazoles via cascade construction of exocyclic and endocyclic S-C bonds.

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The chemical synthesis of proteins

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