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[Cushing's disease]

C Brémont1, H Mosnier-Pudar, J P Luton

  • 1Clinique des maladies endocriniennes et métaboliques Hôpital Cochin, Paris.

La Revue Du Praticien
|June 15, 1996
PubMed
Summary
This summary is machine-generated.

Cushing's disease diagnosis can be challenging due to atypical presentations, requiring thorough investigation. Prompt treatment, primarily pituitary surgery or adrenalectomy, is crucial for managing this serious condition.

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Area of Science:

  • Endocrinology
  • Neurosurgery

Background:

  • Cushing's disease typically presents with distinct clinical and biological features.
  • Atypical and intermittent forms can complicate diagnosis, often requiring extensive investigations.
  • Undetected pituitary microadenomas can be inconspicuous, delaying diagnosis.

Purpose of the Study:

  • To highlight the diagnostic challenges in atypical Cushing's disease presentations.
  • To emphasize the importance of timely diagnosis and treatment.
  • To outline therapeutic strategies for Cushing's disease.

Main Methods:

  • Review of clinical presentations of Cushing's disease.
  • Discussion of diagnostic investigations for pituitary microadenoma.
  • Analysis of treatment outcomes for surgical and medical interventions.

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Main Results:

  • Atypical presentations, particularly intermittent forms, necessitate comprehensive diagnostic workups.
  • Pituitary microadenomas can be subtle and difficult to detect.
  • The disease course can lead to severe, life-threatening complications.

Conclusions:

  • Early and accurate diagnosis of Cushing's disease is vital.
  • Pituitary surgery is the primary treatment modality.
  • Total bilateral adrenalectomy is a viable option for severe or refractory cases.