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Related Experiment Videos

An eruption associated with alphavirus infection

P Autio1, K M Niemi, A L Kariniemi

  • 1Department of Dermatology, Helsinki University, Finland.

The British Journal of Dermatology
|August 1, 1996
PubMed
Summary

Sindbis virus infection can cause skin rashes. Histopathology revealed unique lymphohistiocytic infiltrates around hair follicles, offering new insights into alphavirus-associated dermatoses.

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Area of Science:

  • Virology
  • Dermatology
  • Pathology

Background:

  • Alphaviruses, such as Sindbis virus, are known to cause acute febrile illness with symptoms like papular rashes and arthralgia.
  • Diagnosis of alphavirus infections is typically serological, leaving the histopathological features of associated skin manifestations under-documented.

Observation:

  • This report details two cases of patients experiencing rapidly healing skin eruptions linked to Sindbis virus infection.
  • Skin biopsies from these patients were examined to understand the histopathological characteristics of the rashes.

Findings:

  • Histopathological analysis revealed significant lymphohistiocytic infiltrates surrounding hair follicles in the affected skin.
  • Atypical lymphoid cells were noted within these infiltrates, which are unusual findings for rapidly resolving dermatoses.

Implications:

  • These findings contribute to a better understanding of the dermatopathology associated with Sindbis virus and potentially other alphaviruses.
  • The unique histopathological features observed may aid in the diagnosis and management of alphavirus-induced skin conditions.

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