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Related Experiment Videos

Neurologic abnormalities in infantile autism

R H Haas1, J Townsend, E Courchesne

  • 1Department of Neurosciences, University of California San Diego, La Jolla, USA.

Journal of Child Neurology
|March 1, 1996
PubMed
Summary

Autism is linked to cerebellar and parietal brain abnormalities. Clinical neurologic exams reveal significant differences in autistic children compared to healthy controls, confirming structural and behavioral deficits.

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Clinical Neurology

Background:

  • Autism Spectrum Disorder (ASD) is associated with neuroanatomic, pathologic, and neurobehavioral findings.
  • Previous research suggests potential abnormalities in the cerebellum and parietal lobes in individuals with autism.

Purpose of the Study:

  • To investigate neurologic function in pediatric subjects with autism.
  • To correlate neuroanatomic findings with clinical neurologic examination results in autism.

Main Methods:

  • A standardized neurologic examination protocol was applied.
  • Quantitative magnetic resonance imaging (MRI) was used to assess cerebellar vermis and posterior corpus callosum.
  • Subjects included 28 pediatric autistic individuals and 24 healthy pediatric controls.

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Main Results:

  • Autistic subjects showed quantitative MRI measures suggesting cerebellar vermis hypoplasia or hyperplasia.
  • Abnormalities in the posterior corpus callosum, indicative of posterior cortex issues, were observed in autistic subjects.
  • Clinical neurologic examinations revealed significantly greater abnormalities in cerebellar and parietal function in autistic subjects compared to controls.

Conclusions:

  • Clinical neurologic examination can detect abnormalities in individuals with autism.
  • Structural deficits in autism correlate with observable neurologic and behavioral differences.
  • Cerebellar and parietal lobe function are significantly affected in pediatric autism.