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Effect of water diuresis and water restriction on expression of HSPs-27, -60 and -70 in rat kidney
R Medina1, L Cantley, K Spokes
1Department of Medicine, Beth Israel Hospital, Boston, Massachusetts, USA.
Kidney International
|October 1, 1996
Abstract:
Expression of HSP-27, HSP-60 and HSP-70 was estimated in the cortex, outer medulla and inner medulla (papilla) of rats undergoing water diuresis or water restriction for two days. The mRNAs for HSP-27 and HSP-60 in renal papilla were two- to threefold greater in rats during water restriction than in those excreting a dilute urine, but levels of mRNA for HSP-70 were not reduced by water diuresis and Western analysis for HSP-70 protein showed no difference between water-loaded and water-restricted animals.