Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Baclofen-induced catatonia: modification by serotonergic agents

S B Kasture1, S N Mandhane, C T Chopde

  • 1M. V. P. Samaj's College of Pharmacy, Nashik, India.

Neuropharmacology
|May 1, 1996
PubMed
Summary

Baclofen-induced catatonia in rats is modulated by serotonin (5-HT) pathways. Manipulating these pathways, particularly through agonists and antagonists, significantly alters the catatonic state, offering insights into GABAB receptor function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti - Inflammatory and analgesic Activity of Anacardium Occidentale Leaf Extracts.

Ancient science of life·2012
Same author

Agmatine in the hypothalamic paraventricular nucleus stimulates feeding in rats: involvement of neuropeptide Y.

British journal of pharmacology·2011
Same author

Efficacy study of Prunus amygdalus (almond) nuts in scopolamine-induced amnesia in rats.

Indian journal of pharmacology·2010
Same author

Rapid and Simple RPHPLC Method for the Estimation of Metformin in Rat Plasma.

Indian journal of pharmaceutical sciences·2010
Same author

Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats.

Neuropharmacology·2005
Same author

Effect of leaves of Butea frondosa on stress, anxiety, and cognition in rats.

Pharmacology, biochemistry, and behavior·2004

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Baclofen, a GABAB receptor agonist, induces catatonia in rats, providing a model for studying GABAB receptor function.
  • The central nervous system (CNS) exhibits known reciprocal interactions between serotonin (5-HT) and GABAB receptors.

Purpose of the Study:

  • To investigate how agents affecting serotonergic neurotransmission influence baclofen-induced catatonia in rats.
  • To explore the modulatory role of serotonin pathways on GABAB receptor-mediated behaviors.

Main Methods:

  • Baclofen (10-15 mg/kg, i.p.) was administered to rats to induce catatonia, with severity scored using a defined method.
  • Various serotonergic agents, including fenfluramine, fluoxetine, buspirone, PCPA, cyproheptadine, pindolol, and sulpiride, were administered intraperitoneally at specific doses and timings relative to baclofen injection.

Related Experiment Videos

Main Results:

  • The 5-HT releaser fenfluramine and uptake inhibitor fluoxetine reversed baclofen-induced catatonia.
  • The 5-HT1A agonist buspirone potentiated baclofen-induced catatonia.
  • 5-HT synthesis inhibition (PCPA), non-specific 5-HT antagonism (cyproheptadine), 5-HT1A/1B antagonism (pindolol), and 5-HT2 antagonism (sulpiride) all enhanced baclofen-induced catatonia.

Conclusions:

  • Central serotonergic mechanisms play a significant role in modulating baclofen-induced catatonia.
  • The findings highlight the complex interplay between serotonin and GABAB receptor systems in the CNS.
  • Modulation of serotonergic pathways offers a potential strategy for influencing GABAB receptor-related behaviors.