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Updated: Aug 9, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
Phospholipases: in search of a genetic base of schizophrenia
C J Hudson1, A Lin, D F Horrobin
1Schizophrenia Program, Clarke Institute of Psychiatry, Toronto, Ontario, Canada. hudsonc@cs.clarke-inst.on.ca
Abstract:
Evidence from a variety of clinical and biochemical sources indicates alterations in phospholipid synthesis and activity in schizophrenia. We review a recent study which suggests that a genetic variant near the promotor region of the gene for cytosolic phospholipase A2, the rate-limiting enzyme in the synthesis of prostaglandins from arachidonic acid (AA), is associated with schizophrenia. These findings are consistent with a extensive body of literature which suggests alterations in membrane phospholipids in schizophrenia.
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