Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dendritic cells in immune response induction

G Marland1, A B Bakker, G J Adema

  • 1Department of Tumor Immunology, University Hospital Nijmegen, The Netherlands.

Stem Cells (Dayton, Ohio)
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selective Elimination of Autoreactive B Cells Using Multivalent Polyisocyanopeptide-Based Antigen-Toxin Conjugates.

Biomacromolecules·2026
Same author

MitoTam induces ferroptosis and increases radiosensitivity in head and neck cancer cells.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2024
Same author

Radiotherapy induces an increase in serum antioxidant capacity reflecting tumor response.

Clinical and translational radiation oncology·2024
Same author

Tamoxifen induces radioresistance through NRF2-mediated metabolic reprogramming in breast cancer.

Cancer & metabolism·2023
Same author

Sialic acid blockade in dendritic cells enhances CD8<sup>+</sup> T cell responses by facilitating high-avidity interactions.

Cellular and molecular life sciences : CMLS·2022
Same author

Generation of αCD11b-CpG antibody conjugates for the targeted stimulation of myeloid cells.

Journal of controlled release : official journal of the Controlled Release Society·2021

Dendritic cells (DCs) are professional antigen-presenting cells (APCs) crucial for initiating immune responses by priming naive T cells. Their unique capabilities offer potential for developing novel immunotherapies against diseases like cancer.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are professional antigen-presenting cells (APCs) alongside B lymphocytes and mononuclear phagocytes.
  • DCs possess a unique ability to present antigens to naive T lymphocytes, initiating immune responses.
  • Their specialized function is critical for understanding immune system activation and developing therapeutic strategies.

Purpose of the Study:

  • To review the evidence for DC-mediated priming of naive CD4+ and CD8+ T cells.
  • To discuss current hypotheses regarding the mechanisms behind DC's potent antigen-presenting function.
  • To explore the implications of DC function for the development of immunotherapeutic strategies.

Main Methods:

  • Review of existing literature on dendritic cell function.
  • Analysis of in vitro and in vivo studies on T cell priming by DCs.

Related Experiment Videos

  • Discussion of theoretical models for DC-mediated antigen presentation.

    • Main Results:

    • DCs are central to initiating adaptive immune responses by activating naive T cells.
    • Evidence supports DC-mediated priming of both CD4+ and CD8+ T cells.
    • Potential mechanisms include high expression of antigen-presentation machinery and unidentified factors.

    Conclusions:

    • Dendritic cells play a pivotal role in initiating immune responses.
    • Understanding DC function is key to advancing immunotherapies.
    • DCs hold significant promise for therapeutic applications in oncology and other diseases.