Related Experiment Videos
Development of atopic disease during childhood and its prediction by Phadiatop Paediatric
G Lilja1, H Oman, S G Johansson
1Sachs' Children's Hospital, Karolinska Institute, Stockholm, Sweden.
Insights
Phadiatop Paediatric (PP) shows potential for predicting childhood atopic disease. However, its low sensitivity limits its clinical usefulness in early allergy detection for infants with a family history.
Area of Science:
- Pediatric Allergology
- Immunology
- Diagnostic Testing
Background:
- Early prediction of childhood allergies is crucial in pediatric allergology.
- Evaluating in vitro diagnostic tests for predicting atopic disease development is of significant interest.
Purpose of the Study:
- To assess Phadiatop Paediatric (PP) for predicting atopic disease in infants with a family history.
- To determine if PP measurements in early childhood can forecast atopic disease development within the first five years of life.
Main Methods:
- Phadiatop Paediatric (PP) was evaluated in 134 infants.
- Serum samples were analyzed at 6 months, 18 months, and 5 years.
- The predictive capacity of PP was correlated with the incidence of atopic diseases from birth to 18 months and birth to 5 years.
Main Results:
- A positive PP at 6 months predicted atopic disease in 75% of children by 18 months and 100% by 5 years.
- The predictive value of a positive PP at 18 months for symptoms by 5 years was 80% (based on clinical signs).
- This predictive value decreased to 53% when using positive skin-prick tests as the diagnostic criterion.
Conclusions:
- Circulating IgE antibodies detected by Phadiatop Paediatric can predict childhood atopic disease development.
- The clinical utility of Phadiatop Paediatric is constrained by its low sensitivity, ranging from 22% to 47%.
Background:
Evaluating in vivo and/or in vitro tests for 'early' prediction of childhood allergy is of interest in paediatric allergology.
Objective:
To determine whether the measurement of Phadiatop Paediatric (PP) during early childhood could be used to predict the development of atopic disease during the first 5 years of life among infants with a family history of atopic disease.
Methods:
Phadiatop Paediatric was evaluated in 134 infants. The analysis was performed at 6 months, at 18 months and at 5 years of age and the numbers of available serum samples were 61, 85 and 134, respectively. The potential capacity of the test to predict the development of atopic disease was studied by relating the result of the test, a positive or a negative score, to the accumulated incidence of atopic diseases from birth to 18 months of age and from birth to 5 years of age.
Results:
Three of four children with a positive PP at 6 months of age developed clinical signs/symptoms of atopic disease before 18 months and all four before 5 years of age. The predictive value of a positive test at 18 months for symptoms before 5 years of age was 80% (12/15). If the diagnostic criterion, instead of clinical signs/symptoms of atopic disease, was at least one positive skin-prick test to major food or inhalant allergens, the predictive value of a positive PP-test at 18 months decreased to 53% (8/15).
Conclusion:
Although the presence of circulating IgE antibodies, as detected by Phadiatop Paediatric, can predict the development of atopic diseases during childhood, the usefulness of the test is limited by its low sensitivity (22-47%).