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Oxidative stress and male infertility
D Sanocka1, R Miesel, P Jedrzejczak
1Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
Journal of Andrology
|July 1, 1996
Summary
Oxidative stress markers like superoxide dismutase (SOD) and malonaldehyde were analyzed in male infertility. Low SOD activity correlated with elevated malonaldehyde and xanthine oxidase, suggesting their role in infertility causes.
Area of Science:
- Biochemistry
- Reproductive Biology
- Oxidative Stress Research
Background:
- Oxidative stress is implicated in male infertility.
- Key biomarkers include superoxide dismutase (SOD), catalase (Cat), malonaldehyde, xanthine oxidase (XO), and nitric oxide (NOx).
Purpose of the Study:
- To investigate the activity of oxidative stress-related substances in seminal plasma of infertile males.
- To correlate these activities with andrological criteria.
Main Methods:
- Analysis of 147 seminal plasma samples from normal and infertile males.
- Measurement of SOD, Cat, and XO activity using chemiluminometry.
- Quantification of malonaldehyde and NOx levels via spectrophotometry.
- Semen characterization based on WHO criteria (sperm count, motility, morphology).
Main Results:
- Significant alterations in SOD, XO activities, and malonaldehyde levels were observed in infertile subgroups compared to normozoospermic samples.
- Oligozoospermic samples showed higher SOD activity, while other infertile groups exhibited low SOD levels inversely related to elevated malonaldehyde.
- Diminished SOD activity was associated with increased malonaldehyde and XO levels.
Conclusions:
- The study suggests a significant role for SOD, malonaldehyde, and XO in the etiological evaluation of male infertility.
- These biomarkers may aid in understanding the mechanisms underlying infertility.