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Neurogranin is locally concentrated in rat cortical and hippocampal neurons
M Neuner-Jehle1, J P Denizot, J Mallet
1Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, C.N.R.S. Bât. CERVI, Hôpital de la Pitié Salpêtrière, Paris, France.
Brain Research
|September 9, 1996
Abstract:
The rat protein kinase C substrate neurogranin has a granular distribution in cortical and hippocampal neurons. We demonstrate that in these cells, granular labelling corresponds to a local concentration of neurogranin-immunoreactivity at both the membranes of mitochondria and trans-Golgi vesicles and soma-proximal dendritic shaft and spinal head structures. Our findings suggest that the function of neurogranin could be affected by protein assembly at these cellular sites.