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Identification of gastric related neurones in the rat insular cortex
V G Aleksandrov1, V A Bagaev, A D Nozdrachev
1Laboratory of cortico-visceral Physiology, Pavlov Institute of Physiology, Sankt-Petersburg, Russia. chi@physiology.spb.su
Abstract:
Location peculiarities of insular neurones implicated in the regulation of gastrointestinal motility have been studied in acute experiments on rats. After microinjection of a horseradish peroxidase solution in a part of the dorsal vagal complex that receive gastric afferent inputs, retrogradely labelled cell bodies are observed in a certain area of the agranular and disgranular insular cortex. Electrical stimulation of the insular cortex area had no significant effect on heart and respiration rate but had evoked gastric tone changes. These results suggest that the insular cortex contains a specific cell group that provides direct output to the bulbar 'gastric' centre and takes part in regulation of gastrointestinal functions.