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Congenital cutaneous candidiasis

N Rudolph, A A Tariq, M R Reale

    Archives of Dermatology
    |August 1, 1977
    PubMed

    Insights

    Newborn infants developed a widespread skin rash, progressing from maculopapular to vesicular and bullous lesions. Candida albicans was identified as the cause, indicating potential intrauterine infection.

    Area of Science:

    • Neonatal dermatology
    • Mycology
    • Infectious diseases

    Background:

    • Congenital skin conditions require prompt diagnosis.
    • Fungal infections in newborns can be severe.

    Observation:

    • Three newborns presented with generalized maculopapular rash at birth.
    • The rash evolved into vesicular and bullous lesions with subsequent desquamation.

    Findings:

    • Candida albicans was confirmed via direct smear and culture from skin vesicles.
    • Histologic examination of placentas suggested intrauterine Candida albicans infection in at least two cases.
    • Agglutinating antibodies to Candida were detected in all three infants' sera.

    Implications:

    • This suggests congenital cutaneous candidiasis as a cause of severe neonatal rash.
    • Early diagnosis and treatment are crucial for managing intrauterine fungal infections.
    • Further research into maternal-fetal transmission of Candida is warranted.

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