Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The temporal frequency response function of pattern ERG and VEP: changes in optic neuritis

B Falsini1, V Porciatti

  • 1Eye Clinic, Catholic University, Rome, Italy. md0571@mclink.it

Electroencephalography and Clinical Neurophysiology
|September 1, 1996
PubMed
Summary

Optic neuritis (ON) impairs pattern electroretinograms (PERGs) and visual evoked potentials (VEPs) in affected eyes. Fellow eyes show selective deficits, suggesting distinct retinal and postretinal pathway involvement in ON patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Note: Autoantibodies detection in patients affected by autoimmune retinopathies.

European review for medical and pharmacological sciences·2024
Same author

Autoantibodies detection in patients affected by autoimmune retinopathies.

European review for medical and pharmacological sciences·2023
Same author

In Memory of Professor Derek Pheby.

La Clinica terapeutica·2023
Same author

Human Cloning: Biology, Ethics, and Social Implications.

La Clinica terapeutica·2023
Same author

Bioetics Issues of Artificial Placenta and Artificial Womb Technology.

La Clinica terapeutica·2023
Same author

Neurofibromatosis type 1-associated optic pathway gliomas: pathogenesis and emerging treatments.

European review for medical and pharmacological sciences·2023

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Visual electrophysiology

Background:

  • Optic neuritis (ON) is an inflammatory condition affecting the optic nerve, leading to visual dysfunction.
  • Pattern electroretinograms (PERGs) and visual evoked potentials (VEPs) are electrophysiological tools used to assess the integrity of the visual pathway.
  • Temporal frequency (TF) analysis of PERGs and VEPs can reveal specific deficits in visual processing.

Purpose of the Study:

  • To investigate the impact of unilateral optic neuritis on steady-state PERGs and VEPs across a range of temporal frequencies.
  • To differentiate between retinal and postretinal pathway involvement in affected and fellow eyes of ON patients.
  • To characterize the temporal frequency-dependent abnormalities in visual processing following optic neuritis.

Main Methods:

Related Experiment Videos

  • Recorded steady-state PERGs and VEPs in response to sinusoidal gratings at various temporal frequencies (4-28 Hz).
  • Analyzed amplitude and phase of the second harmonic of the responses.
  • Estimated apparent latencies from phase lag as a function of temporal frequency.

Main Results:

  • Affected (ON) eyes showed reduced PERG and VEP amplitudes at both low and high TFs.
  • Fellow eyes exhibited selectively reduced PERG amplitudes at low TFs.
  • Both ON and fellow eyes displayed delayed PERG apparent latencies; VEP latencies were delayed in ON eyes at all TFs and in fellow eyes at high TFs.

Conclusions:

  • Optic neuritis causes non-selective PERG and VEP abnormalities in affected eyes.
  • Fellow eyes demonstrate selective temporal frequency deficits, suggesting differential impairment of parvocellular and magnocellular pathways.
  • VEP abnormalities in ON eyes may be partly explained by concurrent PERG deficits.