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Pregnancy results after ovum donation following one to seven embryo transfers
T Mantzavinos1, F Dimitriadou, N Kanakas
1Euromedica Institute of High Technology, Athens, Greece.
Objective:
To determine whether failure to achieve pregnancy after repeated ET after ovum donation was due to an endometrial defect or to the embryo quality.
Design:
Retrospective data analysis.
Setting:
A private infertility center.
Patient(S):
Four hundred sixty-seven donors (513 cycles) undergoing IVF donating oocytes to 266 recipients (423 cycles).
Intervention(S):
Hormonal endometrial preparation with increasing dosages of valerate E2 (2,4, and 6 mg) and 100 mg of P.
Main Outcome Measure(S):
Pregnancy rates (PRs) and abortion rates in patients undergoing one to seven ETs after ovum donation.
Result(S):
Pregnancy rates in recipients that had one or two ETs were significantly higher (34.8%) compared with those of recipients having three or more ETs (15.1%). Abortion rates were significantly higher (54.5%) in recipients repeating more than three ETs than in the recipients having one or two ETs (29.1%).
Conclusion(S):
Recipients that had failed to establish a pregnancy after two ETs had a lower PR in successive attempts, possibly because of a defect of their endometrial lining.