Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age-related differences in post-yield damage in human cortical bone. Experiment and model

A C Courtney1, W C Hayes, L J Gibson

  • 1Department of Orthopedic Research, Charles A. Dana Research Institute, Harvard-Thorndike Biomechanics Laboratory, Beth Israel Hospital, Boston, MA, USA.

Journal of Biomechanics
|November 1, 1996
PubMed
Summary

Older human cortical bone exhibits more microcracks, potentially explaining its reduced mechanical properties. Even young bone shows damage under strain, indicating a need for further research into bone microdamage.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure and mechanics of water-holding feathers of Namaqua sandgrouse (<i>Pterocles namaqua</i>).

Journal of the Royal Society, Interface·2023
Same author

3D printed structures for modeling the Young's modulus of bamboo parenchyma.

Acta biomaterialia·2018
Same author

Prevalence of infertility and help seeking among 15 000 women and men.

Human reproduction (Oxford, England)·2016
Same author

The structure and mechanics of Moso bamboo material.

Journal of the Royal Society, Interface·2014
Same author

Stress concentration around an atelectatic region: a finite element model.

Respiratory physiology & neurobiology·2014
Same author

Strength reductions of thoracic vertebrae in the presence of transcortical osseous defects: effects of defect location, pedicle disruption, and defect size.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2010

Area of Science:

  • Biomechanical engineering
  • Skeletal biology
  • Materials science

Background:

  • Quantitative comparisons between mechanical testing and microscopic damage in cortical bone are scarce.
  • Age-related decline in bone mechanical properties is a significant health concern.

Purpose of the Study:

  • To investigate if age-related degradation of human cortical bone's mechanical properties correlates with increased microcrack damage.
  • To compare microcrack formation in bone from young adults versus elderly individuals under mechanical loading.

Main Methods:

  • Mechanical testing of human cortical bone specimens from young and elderly donors.
  • Microscopic analysis to quantify microcrack formation and compare tested specimens with controls.
  • Development of a microstructurally based model to interpret mechanical test results.

Related Experiment Videos

Main Results:

  • Elderly bone showed a significant decrease in yield stress (10%) compared to young bone.
  • Both groups experienced a 34% decrease in modulus after loading to 1% strain.
  • Elderly bone had significantly more microcracks than young bone, both in controls and after testing.

Conclusions:

  • Increased microcracks in older bone likely contribute to its reduced mechanical properties.
  • Older bone is more susceptible to microcrack formation at equivalent strain levels.
  • Young adult bone also sustains damage, warranting further investigation into its mechanisms.