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Development and validation of a reversed-phase liquid chromatographic method for analysis of aspirin and warfarin in
E R Montgomery1, S Taylor, J Segretario
1DuPont Merck Pharmaceutical Company, Experimental Station, Wilmington, DE 19880-0353, USA.
Journal of Pharmaceutical and Biomedical Analysis
|October 1, 1996
Abstract:
A stability-indicating liquid chromatographic method for the simultaneous analysis of aspirin and warfarin in warfarin sodium/aspirin combination (DuP 647) tablets has been developed and validated. This paper presents linearity, accuracy, precision, robustness, recovery, limits of detection and quantitation, and cross-validation data. The method has been shown to be specific and stability-indicating, and to give results comparable to existing methods for the individual components. Solution stability has been optimized for routine analysis.