The black widow: is she deadly to children?
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Updated: Nov 3, 2026

Extraction of Venom and Venom Gland Microdissections from Spiders for Proteomic and Transcriptomic Analyses
Published on: November 3, 2014
R Woestman1, R Perkin, D Van Stralen
1Loma Linda University Children's Hospital, CA, USA.
Insights
Black widow spider envenomation (BWSE) in children typically causes abdominal pain and hypertension but rarely leads to severe complications or death. Prompt treatment, including antivenin, can accelerate symptom relief.
Area of Science:
- Toxicology
- Pediatric Medicine
- Epidemiology
Background:
- Black widow spider envenomation (BWSE) is a significant concern in pediatric populations.
- Understanding the clinical presentation and outcomes of BWSE in children is crucial for effective management.
Purpose of the Study:
- To assess the morbidity and mortality associated with BWSE in pediatric patients.
- To provide recommendations for optimal therapeutic strategies for BWSE in children.
Main Methods:
- Retrospective chart review of pediatric patients diagnosed with BWSE.
- Data collected from an urban pediatric tertiary care hospital over a 10-year period (1984-1994).
Main Results:
- The study included 12 pediatric patients aged 15 months to 18 years.
- Common symptoms included abdominal pain (100%), hypertension (92%), muscle complaints (75%), and a target lesion (75%).
- Eight patients recovered within 24 hours; antivenin appeared to hasten symptom relief. No deaths or complications were reported.
Conclusions:
- BWSE in children is characterized by significant systemic effects, notably abdominal pain and hypertension.
- While symptoms can be severe, BWSE in this pediatric cohort had no mortality or complications.
- Antivenin therapy may expedite recovery from BWSE symptoms in children.
Abstract:
Pediatric cases of black widow spider envenomation (BWSE) were reviewed in order to assess the morbidity and mortality in children with BWSE, and to make recommendations for optimal therapy. The methodology includes a retrospective chart review in an urban pediatric tertiary care hospital. Included were all pediatric patients admitted with the BWSE diagnosis in the last 10 years (1984-1994). The results are based on 12 children with ages ranging from 15 months to 18 years. The BWSE syndrome is characterized by several common systemic effects. Our cases revealed abdominal pain (100%), hypertension (92%), muscle complaints (75%), a target lesion (75%), and irritability/agitation (66%) as the most common symptoms. Treatments used included antivenin, calcium gluconate, benzodiazepines, and opioids. Eight of 12 patients recovered (had relief of symptoms) within 24 hours, often by 12 hours. Antivenin did appear to bring quicker relief of symptoms. Hypertension was severe but asymptomatic in all patients. There were no complications or deaths resulting from BWSE.
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