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Catecholamines inhibit alpha/beta interferon production induced by lipopolysaccharide
1Laboratorio de Immunología, Universidad de Guadalajara, Jal, Mexico.
Abstract:
In vitro incubation of Listeria monocytogenes immune spleen cells in the presence of the catecholamines epinephrine or norepinephrine inhibited the alpha/beta-interferon (IFN alpha/beta) synthesis induced by the mitogen lipopolysaccharide, in a manner that appeared to be concentration-dependent. Moreover, the inhibitory effect of both catecholamines epinephrine and norepinephrine on the synthesis of IFN alpha/beta was prevented by incubating immune spleen cells in the presence of propranolol, a beta-adrenergic antagonist agent.
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