Related Experiment Video
Updated: Aug 10, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
Inhibition of gamma interferon synthesis by catecholamines
1Laboratorio de Immunologia Centro, Universitario de Ciencias de la Salud, Universidad de Guadalajara, Mexico.
Abstract:
In vitro incubation of Listeria monocytogenes immune spleen cells in the presence of the catecholamines epinephrine or norepinephrine inhibited the gamma interferon (IFN-gamma) synthesis induced by the mitogen PHA, in a manner that appeared to be concentration dependent. Moreover, the inhibitory effect of both catecholamines epinephrine and norepinephrine on the synthesis of IFN-gamma was prevented by incubating immune spleen cells in the presence of propranolol, a beta adrenergic antagonist agent.
Related Concept Videos
Eukaryotic Transcription Inhibitors
Eukaryotic transcription inhibitors usually contain two distinct domains, a DNA...
GPCRs Regulate Adenylyl Cylase Activity
Two...
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
Indirect-Acting Cholinergic Agonists: Pharmacological Actions
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
Inhibitors of Viral Protein Synthesis
Antiviral Nucleoside Inhibitors

