Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interleukin-1 in cerebral ischemia

A L Betz1, G P Schielke, G Y Yang

  • 1Department of Surgery (Neurosurgery), University of Michigan, Ann Arbor 48109-0532, USA.

The Keio Journal of Medicine
|September 1, 1996
PubMed
Summary

Interleukin-1 beta (IL-1 beta) significantly contributes to brain injury following ischemia. Blocking IL-1 beta activity with IL-1 receptor antagonist (IL-1ra) reduces infarct volume, highlighting its therapeutic potential.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Curative effects of ultrathin anterolateral femoral flap in one-stage split-finger repair of palmar combined with multiple finger wounds].

Zhonghua shao shang yu chuang mian xiu fu za zhi·2023
Same author

[A prospective study on the expansion rule of the directional skin and soft tissue expander in abdominal scar reconstruction].

Zhonghua shao shang yu chuang mian xiu fu za zhi·2023
Same author

[Clinical effects of free hallux-nail flap combined with the second toe composite tissue flap in the reconstruction of damaged thumb after electrical burns].

Zhonghua shao shang yu chuang mian xiu fu za zhi·2022
Same author

LncRNA SNHG17 acts as a ceRNA of miR-324-3p to contribute the progression of osteosarcoma.

Journal of biological regulators and homeostatic agents·2020
Same author

Short communication: A decrease in diameter of milk fat globules accompanies milk fat depression induced by conjugated linoleic acid supplementation in lactating dairy cows.

Journal of dairy science·2020
Same author

[Early diagnosis and treatment for burn complicated with severe paroxysmal sympathetic hyper-activity].

Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns·2019

Area of Science:

  • Neuroscience
  • Immunology
  • Pathology

Background:

  • Interleukin-1 beta (IL-1 beta) is implicated in ischemic brain injury.
  • IL-1 beta mRNA and protein are upregulated early during ischemia.
  • IL-1 beta administration exacerbates edema formation in ischemic brain.

Purpose of the Study:

  • To investigate the role of IL-1 beta in ischemic brain injury.
  • To evaluate the therapeutic potential of blocking IL-1 beta signaling.

Main Methods:

  • Administering IL-1 receptor antagonist (IL-1ra) intraventricularly.
  • Overexpressing IL-1ra in brain cells via adenoviral vectors.
  • Utilizing IL-1 beta converting enzyme (ICE) knockout mice.

Main Results:

  • Intraventricular IL-1ra injection reduced infarct volume in focal ischemia.
  • Overexpression of IL-1ra via adenoviral vectors decreased ischemic injury.
  • ICE knockout mice exhibited reduced ischemic brain injury.
  • Potential mechanisms include glial activation, cytokine induction, and free radical release.

Conclusions:

  • IL-1 beta plays a critical role in mediating ischemic brain injury.
  • Inhibition of IL-1 beta signaling, via IL-1ra, offers a promising therapeutic strategy.
  • Further research is needed to elucidate the precise molecular mechanisms of IL-1 beta-induced injury.

Related Experiment Videos