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Mammary gland neoplasia
D A Neumann1, T M Crisp, S S Olin
1ILSI Risk Science Institute, Washington, DC 20036-4810, USA.
Environmental Health Perspectives
|September 1, 1996
Summary
Translating rodent cancer findings to human health risks is challenging. This review compares rodent and human mammary cancer mechanisms, focusing on reproductive hormones, to improve risk assessment and guide future research.
Area of Science:
- Toxicology and Carcinogenesis
- Comparative Oncology
- Reproductive Endocrinology
Background:
- Interpreting rodent carcinogenicity data for human health risk assessment remains a significant challenge.
- Comparative analysis of rodent and human biological processes is crucial for accurate extrapolation.
- Understanding species-specific mechanisms is key to refining risk assessment models.