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Related Experiment Videos

Glycopeptide resistance in enterococci

M Arthur1, P Reynolds, P Courvalin

  • 1Unité des Agents Antibactériens, Centre National de la Recherche Scientifique, EP J0058, Institut Pasteur, Paris, France. Michel.Arthur@pasteur.fr

Trends in Microbiology
|October 1, 1996
PubMed
Summary

Glycopeptide resistance in enterococci arises from altered peptidoglycan precursors. Mobile resistance genes and adaptable resistance proteins suggest potential spread to other bacterial species.

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Antimicrobial Resistance

Background:

  • Enterococci are a significant cause of nosocomial infections.
  • Glycopeptide antibiotics (e.g., vancomycin) are crucial for treating serious enterococcal infections.
  • Emergence of glycopeptide resistance in enterococci poses a major therapeutic challenge.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying glycopeptide resistance in enterococci.
  • To assess the potential for dissemination of glycopeptide resistance determinants to other bacterial pathogens.

Main Methods:

  • Analysis of peptidoglycan precursor synthesis in resistant enterococcal strains.
  • Investigation of the genetic elements conferring resistance (e.g., van genes).

Related Experiment Videos

  • Evaluation of the mobility of resistance genes via transposition and conjugation.

    • Main Results:

    • Glycopeptide resistance is mediated by the synthesis of peptidoglycan precursors with reduced antibiotic binding affinity.
    • Resistance genes are located on mobile genetic elements, facilitating their spread.
    • Resistance proteins can interfere with normal cell wall synthesis in various bacterial hosts.

    Conclusions:

    • The molecular basis of glycopeptide resistance in enterococci involves altered cell wall precursor synthesis.
    • The inherent mobility of resistance genes and adaptability of resistance mechanisms predict the potential for inter-species dissemination.
    • Anticipation and monitoring of resistance spread to other bacterial species are critical for public health.