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Related Experiment Videos

Histological response to stent graft therapy

D Eton1, D L Warner, C Owens

  • 1Department of Surgery, University of Illinois at Chicago, USA.

Circulation
|November 1, 1996
PubMed
Summary

Stent graft technology successfully excluded blood flow in canine abdominal aortic dilation (AAD), preventing further dilation. Histology revealed a collagen-rich neointima incorporating the graft, despite some thrombus recanalization.

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Area of Science:

  • Vascular surgery
  • Biomaterials science
  • Histopathology

Background:

  • Endoluminal exclusion of blood flow using stent graft technology is a novel approach.
  • Abdominal aortic dilation (AAD) models in canines provide insights into vascular repair mechanisms.

Purpose of the Study:

  • To investigate the histological outcomes of endoluminal blood flow exclusion using stent graft technology in a canine model of abdominal aortic dilation.
  • To assess the long-term effects of stent graft incorporation and neointimal formation.

Main Methods:

  • Mongrel dogs underwent infrarenal aortoplasty with a vein patch, creating abdominal aortic dilation (AAD).
  • Transfemoral placement of a Dacron stent graft was performed 4 months later.
  • Histological analysis (H&E, EVG, Masson's trichrome) was conducted at 6 and 12 months post-stent graft placement.

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Main Results:

  • Stent grafts were fully incorporated into a collagen-rich, elastin-poor neointima within 6-12 months.
  • Laminated thrombus formed after stent graft placement, with microscopic recanalization observed at 12 months.
  • No significant AAD growth was noted, and vein patch fibrosis occurred by 1 year.

Conclusions:

  • Stent graft placement effectively stabilized AADs with patent side branches, preventing further dilation.
  • The neointima formed around the stent graft was characterized by high collagen and low elastin content.
  • Microscopic thrombus recanalization did not impede the overall success of the endovascular repair.