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LC50 of 2-bromopropane
1Department of Industrial Toxicology, Industrial Health Research Institute Korea Industrial Safety Corporation, Bupyung-gu, Inchon, Korea.
Industrial Health
|January 1, 1996
Summary
The lethal concentration 50 (LC50) for 2-bromopropane in mice was determined to be 31,171 ppm. This study reexamined the toxicity of 2-bromopropane following standardized OECD guidelines.
Area of Science:
- Toxicology
- Occupational Health
- Chemical Safety
Background:
- 2-bromopropane is a chemical with potential occupational exposure risks.
- Accurate toxicity data is crucial for risk assessment and safety protocols.
Purpose of the Study:
- To reexamine the LC50 of 2-bromopropane in ICR mice.
- To adhere to OECD guidelines for standardized toxicity testing.
Main Methods:
- Inhalation exposure of mice (3 males, 3 females) to five concentrations of 2-bromopropane for 4 hours.
- Observation of surviving and deceased animals for 14 days post-exposure.
- Calculation of LC50 using a dose-mortality curve at a 95% confidence level.
Main Results:
- The determined LC50 for 2-bromopropane was 31,171 ppm.
- The lowest lethal concentration (LLC) was below 29,528 ppm.
- The lethal concentration for 100% mortality (LC100) was above 32,905 ppm.
Conclusions:
- The reexamined LC50 provides updated toxicity data for 2-bromopropane.
- Findings support the establishment of safety limits for handling 2-bromopropane.
- The study confirms the acute inhalation toxicity of 2-bromopropane in mice.