Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methazolamide for essential voice tremor

K Busenbark1, L Ramig, C Dromey

  • 1Department of Neurology, University of Kansas Medical Center, Kansas City 66160-7314, USA.

Neurology
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Subthalamic deep brain stimulation and impulse control in Parkinson's disease.

European journal of neurology·2009
Same author

A comparison of Parkinson's disease symptoms and self-reported functioning and well being.

Parkinsonism & related disorders·2008
Same author

Topiramate in essential tremor: a double-blind, placebo-controlled trial.

Neurology·2006
Same author

Apolipoprotein E controls the risk and age at onset of Parkinson disease.

Neurology·2004
Same author

Advances in the treatment of Parkinson's disease.

Drugs of today (Barcelona, Spain : 1998)·2004
Same author

Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease.

Neurology·2003
Same journal

Factors Associated With Disability Improvement and Worsening Independent of Attacks in Patients With AQP4-IgG+ NMOSD and MOGAD: A Multicenter Cohort Study.

Neurology·2026
Same journal

Cost-Effectiveness of Intracranial Aneurysm Screening: A Systematic Review.

Neurology·2026
Same journal

Rare Eating Epilepsy: Co-Occurrence of Focal Cortical Dysplasia and Gray Matter Heterotopia.

Neurology·2026
Same journal

Spatiotemporal Associations Between Cortical Microinfarcts and Cortical Superficial Siderosis in Cerebral Amyloid Angiopathy.

Neurology·2026
Same journal

Blood-Brain Barrier Disruption Before Interhospital Transfer for Thrombectomy and Clinical Outcome.

Neurology·2026
Same journal

At Death's Door: Cytosolic Dopamine in Patients With Parkinson Disease.

Neurology·2026
See all related articles

Methazolamide showed limited effectiveness for essential voice tremor, despite altering voice frequency modulation. The drug also commonly caused side effects in patients.

Area of Science:

  • Neurology
  • Otolaryngology
  • Pharmacology

Background:

  • Essential voice tremor is a neurological disorder affecting vocalization.
  • Current treatment options for essential voice tremor have limitations.

Purpose of the Study:

  • To evaluate the safety and efficacy of methazolamide in patients with essential voice tremor.

Main Methods:

  • A placebo-controlled, blinded investigation involving nine patients.
  • Dosage averaged 168 mg/day of methazolamide.
  • Objective voice analysis using digital audio tape recordings.

Main Results:

  • No significant differences in physician or patient clinical ratings were observed.
  • Amplitude modulation showed no significant change.

Related Experiment Videos

  • Frequency modulation was significantly altered by methazolamide.
  • Common side effects were reported with methazolamide use.

    • Conclusions:

    • Methazolamide demonstrates limited clinical usefulness for treating essential voice tremor.
    • The observed alteration in frequency modulation did not translate to clinical benefit.
    • Further research may be needed to explore alternative treatments for essential voice tremor.