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Ringlike structures in fine needle aspirates from the breast

R K Gupta1

  • 1Department of Laboratory Services, Wellington Hospital and School of Medicine, New Zealand.

Cytopathology : Official Journal of the British Society for Clinical Cytology
|October 1, 1996
PubMed
Summary

This study identified ringlike structures resembling Liesegang rings (LRs) in breast fine needle aspirates (FNAs). Awareness of these structures is crucial to prevent misdiagnosis as ova or parasites.

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Area of Science:

  • Pathology
  • Cytopathology
  • Breast Imaging

Background:

  • Ringlike structures, termed Liesegang rings (LRs), have been observed in various biological samples.
  • Their presence in breast fine needle aspirates (FNAs) is uncommon and can pose diagnostic challenges.

Purpose of the Study:

  • To describe the morphological characteristics of Liesegang rings (LRs) identified in breast FNAs.
  • To highlight the importance of recognizing LRs to avoid misdiagnosis in breast cytology.

Main Methods:

  • Retrospective analysis of four breast FNAs over 13 years.
  • Morphological examination of ringlike structures, including characteristic double-layered walls and central amorphous material.
  • Polarized light microscopy and Congo red staining.
  • Immunohistochemical staining for various markers (calcium, iron, mucus, glycogen, amyloid, cytokeratin, epithelial membrane antigen).

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Main Results:

  • Four cases of breast FNAs revealed spherical, ringlike structures consistent with Liesegang rings (LRs).
  • These structures exhibited a distinct double outer wall with striations and an amorphous central nidus.
  • They were non-refractile under polarized light and negative for birefringence with Congo red.
  • Immunohistochemical stains for common cellular and extracellular components were negative.

Conclusions:

  • Liesegang rings (LRs) can occur in breast fine needle aspirates (FNAs).
  • Their unique morphology should be recognized to differentiate them from other entities.
  • Consideration of LRs in breast aspirates is essential to prevent misdiagnosis, particularly of parasitic infections.