Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immune deviation: a historical perspective

C R Parish1

  • 1Division of Immunology and Cell Biology, John Curtin School of Medical Research, Australian National University, Canberra, Australia.

Immunology and Cell Biology
|October 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The influence of platelet membranes on tumour cell behaviour.

Cancer metastasis reviews·2017
Same author

Islet heparan sulfate but not heparan sulfate proteoglycan core protein is lost during islet isolation and undergoes recovery post-islet transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

Presence of receptors for self MHC antigens on non-T cells.

Immunology today·2014
Same author

Glycosyltransferases and T-cell recognition.

Immunology today·2014
Same author

Beware of NK cells in pre-clinical metastasis models.

Clinical & experimental metastasis·2013
Same author

Unexpected new roles for heparanase in Type 1 diabetes and immune gene regulation.

Matrix biology : journal of the International Society for Matrix Biology·2013
Same journal

Multi-Omics Comes of Age: Immune Profiling of Human Aging.

Immunology and cell biology·2026
Same journal

Mechanisms of Therapeutic Resistance and Recent Advances in Glioblastoma Treatment.

Immunology and cell biology·2026
Same journal

Ancestry Matters in Decoding Immunity.

Immunology and cell biology·2026
Same journal

Improving COVID-19 Vaccine Uptake Among Ethnic Minority Communities in Wales: A Community-Based Approach.

Immunology and cell biology·2026
Same journal

4-1BB Expression and Signaling Regulates MAIT Cell Activation and Effector Functions.

Immunology and cell biology·2026
Same journal

Highlights of 2025: Advances in the T-Cell Regulation of Germinal Center Response.

Immunology and cell biology·2026
See all related articles

Early studies on immune deviation reveal an inverse relationship between delayed-type hypersensitivity (DTH) and antibody formation. Key factors influencing these responses and cellular mechanisms remain critical for understanding immune regulation.

Area of Science:

  • Immunology
  • Cellular immunology
  • Immune regulation

Background:

  • Review of early studies (1966-1976) on immune deviation using flagellin antigen.
  • Focus on the relationship between delayed-type hypersensitivity (DTH) and antibody formation.
  • Exploration of factors determining immune response type.

Observation:

  • Flagellin antigen studies established an inverse relationship between DTH and antibody formation.
  • Identification of key factors influencing DTH versus antibody production.
  • Cellular analyses revealed distinct T cell subsets mediating DTH and T cell help.

Findings:

  • Different T cell subsets mediate DTH and T cell help.
  • Suppressor mechanisms are involved in maintaining immune deviation.

Related Experiment Videos

  • Fundamental questions regarding signalling events, B cell roles, and CD8+ T cell suppression persist.

    • Implications:

    • The delineated factors remain highly relevant for current immunological research.
    • Understanding immune deviation mechanisms is crucial for immune system regulation.
    • Unanswered questions highlight areas for future investigation in cellular immunology.